When a skin substitute may be needed


Every year about 34.5 million chronic wounds are treated globally. Chronic wounds present an enormous physical, social, and economic burden worldwide, and their incidence is on the rise with an aging population. It has been estimated that chronic wounds affect 120 per 100,000 people aged between 45 and 65 years and increases to 800 per 100,000 people aged over 75 year. Chronic wounds can result from a number of different causes, such as diabetes, pressure ulcers, atrial and venous insufficiency, vasculitis, and burns. Additional complications, including infections, necrosis, tissue hypoxia, and exudates, represent further challenges in dealing with chronic wounds. Lifestyle choices, like poor nutrition, obesity, excessive alcohol consumption, and smoking, can also adversely affect healing in chronic wounds.

In the chronic wound, the balance between production and degradation of molecules is lost. Normal wound healing progresses through three stages. The first, inflammation, can last from 2 to 4 days from the time of injury. Platelets in the wound release factors that recruit neutrophils and monocytes (macrophages), which in turn attract lymphocytes and fibroblasts to the site of injury. The second, proliferatory stage overlaps the inflammatory stage, starting at about day 3 and lasting for several days. This stage is characterized by angiogenesis, collagen formation, and epithelialization mediated by fibroblasts. It is complete when a balance is achieved between collagen formation and its continuous breakdown by matrix metalloproteases (MMPs). The third and final stage, remodeling, can last a year or more. During this phase, collagen continues remodeling, fibroblasts differentiate into myofibroblasts, vascularity decreases, and tissue strength increases.

Kerecis is committed to the prevention and treatment of chronic wounds. That’s why Kerecis has developed a unique solution that helps the wound regain its wound healing balance to help the wound heal quickly.

Visit Kerecis™ Omega3 Wound for more information about our product.

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