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Surgical

SurgiClose®

Fish skin application for Surgical Wounds
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SurgiClose is intact fish skin intended for the management of trauma wounds and surgical wounds in the operating room. Because there is no known risk of viral or prion disease transfer from North-Atlantic cod to humans, the fish skin only needs mild processing with our proprietary method.[2]

This process preserves the skin’s natural qualities,[2] including: its three-dimensional structure, mechanical properties, molecular organization, and composition.[1-4]

The product is homologous to human skin1 and when applied to damaged tissue, such as partial thickness burns or wounds, helps to support the body’s own cells to regenerate tissue.[5-12]

SurgiClose® Benefits

Promotes incorporation and cell ingrowth
Preserved microstructure facilitates dermal regeneration
Rapid neovascularization through naturally porous skin structure
Natural barrier protecting against environmental threats
SurgiClose

Standard

SurgiClose is intact fish skin that comes in various sizes and variations.

Description & Sizing
SKU
Total Units
7 x 10 cm
50205S03D0D
70
7 x 20 cm
50205S21D0D
140
SurgiClose

Silicone

SurgiClose Silicone provides a breakthrough balance of protection, breathability, and stability with a combination of fenestrated fish skin and a highly-refined, porous silicone contact layer.

Description & Sizing
SKU
Total Units
6 x 14 cm
50214F55D0D
84
10 x 18 cm
50214F56D0D
180
SurgiClose

Micro

SurgiClose Micro is intact fish skin that has been fragmented. It offers more surface area than the non-fragmented version, and is designed to adhere to, fill deep wound spaces and irregular geometries.

Description & Sizing
SKU
Total Units
19 sq cm
50205P02D0D
19
38 sq cm
50205P04D0D
38
95 sq cm
50205P31D0D
95
SurgiClose

Meshed 2:1

2:1 pre-meshed intact fish-skin graft designed to expand and cover larger wounds. Provides a viable clinical and economic solution for large wounds

Description & Sizing
SKU
Total Units
4 x 6 cm meshed 2:1
50205N20D0D
up to 43
6 x 8 cm meshed 2:1
50205N18D0D
up to 86
7 x 10 cm meshed 2:1
50205N03D0D
up to 126
7 x 20 cm meshed 2:1
50205N21D0D
up to 252
250 cm2 meshed 2:1
50205N24D0D
up to 450
300 cm2 meshed 2:1
50205N23D0D
up to 540
SurgiClose Meshed 2:1

Intended Use

Kerecis® SurgiClose® is indicated for the management of wounds including:

  • Partial and full thickness wounds
  • Pressure ulcers
  • Chronic vascular ulcers
  • Diabetic ulcers
  • Trauma wounds (abrasions, lacerations, second-degree burns, skin tears)
  • Surgical wounds (donor site/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)
  • Draining wounds

Instructions for Use – SurgiClose (USA)

Instructions for Use – SurgiClose Silicone (USA)

 

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From the town of Isafjordur in northwest Iceland, Kerecis develops, manufactures, and sells patented fish skin soft tissue regeneration products that have regulatory approval in the United States, Europe and several other jurisdictions.

Important Information

This website and its content is not intended to provide diagnosis, treatment, or medical advice. Products, services, information, and other content provided on this website, including information provided directly or through links to third-party websites, are for informational purposes only. Information on this website should not be considered a substitute for professional advice from a healthcare provider. Always consult with a physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options.

Products and their variations may not be available in all countries and could be known under different trade names. Products, product names, indications, and claims vary by jurisdiction. Always verify with your local healthcare professional and consult the printed package information before use. Information on this website may not be current and might not reflect the latest product labeling - please refer to latest IFU's on the website. For questions about product availability, please contact your Kerecis representative or use the contact form on our website.

Products are derived from fish sources and should not be used in patients with a known allergy to fish or sensitivity to fish products. Note that fish allergy is distinct from shellfish allergy. SurgiClose Silicone and Shield products contain silicone and are not suitable for patients with silicone sensitivity. SurgiBind is not indicated for procedures requiring load-bearing support, such as hernia repair, for intraperitoneal organ contact, or where a bridging effect is needed. SurgiBind Tendon Protect is not indicated to replace or repair the damaged tendon or to reinforce the strength of any tendon repair. Always follow the product’s labeling for indications and contraindications.

A surgeon must always rely on their professional clinical judgment when deciding whether to use a specific product for a patient. Kerecis does not dispense medical advice and strongly recommends that surgeons be adequately trained in the use of its products before employing them in surgical procedures. The information provided on this website is intended to demonstrate the product offerings and should not replace the package insert, product label, or instructions for use. For regulatory and medical practice reasons, product availability may vary by market. Contact your Kerecis representative for further clarification.

1

Magnusson, S. et al. Regenerative and Antibacterial Properties of Acellular Fish Skin Grafts and Human Amnion/Chorion Membrane: Implications for Tissue Preservation in Combat Casualty Care. Mil. Med. 182, 383–388 (2017).

2

Baldursson, B. T. et al. Healing rate and autoimmune safety of full-thickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: a non-inferiority study. Int. J. Low. Extrem. Wounds 14, (2015).

3

Magnusson, S. et al. Decellularized fish skin: characteristics that support tissue repair. Laeknabladid 101, 567–573 (2015)

4

Alam, K. & Jeffery, S. L. A. Acellular Fish Skin Grafts for Management of Split Thickness Donor Sites and Partial Thickness Burns: A Case Series. Mil Med. 184(Suppl 1):16-20 (2019).

5

Pujji, O. & Jeffery, S. L. A. Safe burn excision prior to military repatriation: an achievable goal? BMJ Military Health.164: 358-359 (2018).

6

Shupp, J. W. et al. Fish Skin Compared to Cadaver Skin as a Temporary Covering for Full Thickness Burns: An Early Feasibility Trial. Poster presented at: AMUS 2020 Annual Meeting (2020).

7

Badois, N. et al., Acellular fish skin matrix on thinskin graft donor sites: a preliminary study. J Wound Care 28. 624–628 (2019).

8

Kirsner, R. S. et al. Fish skin grafts compared to human amnion/chorion membrane allografts: A double-blind, prospective, randomized clinical trial of acute wound healing. Wound Repair Regen. 28, 75–80 (2020).

9

Lantis, J.C, 2nd, et al. Final efficacy and cost analysis of a fish skin graft vs standard of care in the management of chronic diabetic foot ulcers: a prospective, multicenter, randomized controlled clinical trial. Wounds. 35(4): 71-79 (2023).

10

Wallner, C. et al. A Comparison of Intact Piscine Skin, Split-thickness Skin Graft, and Lactic Acid Membrane in Treating Superficial and Deep Burn Wounds Following Enzymatic Debridement, J Burn Care Res. 42 (Suppl 1): 125-126 (2021).

11

Stone, R. 2nd, et al. Omega-3 Rich Fish Skin Grafts Reduce Donor Skin Requirements for Full Thickness Burns. J. Burn Care Res. 39, S234–S235 (2018).

12

Stone, R. 2nd, et al. Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft. Int J Mol Sci. 2021;22(4):1590 (2021).

13

Evangelatov, A., & Pankov, R. The evolution of three-dimensional cell cultures towards unimpeded regenerative medicine and tissue engineering. In Andrades, J. A. [Ed.] Regenerative medicine and tissue engineering. IntechOpen (2013).

14

Wang, Y. et al. Burn injury: challenges and advances in burn wound healing, infection, pain and scarring. Advanced drug delivery reviews, 123, 3-17 (2018).

15

Dardari D, Piaggesi A, Potier L, Sultan A, Diener H, Francois M, Dorweiler B, Bouillet B, M’Bemba J, Chaillous L, Clerici G, Kessler L, Wetzel-Roth W, Storck M, Davidsson OB, Baldursson B, Kjartansson H, Lantis JC, Charpentier G. Intact Fish Skin Graft to Treat Deep Diabetic Foot Ulcers. NEJM Evid. 2024 Oct 4, doi: 10.1056

16

*Image on left: Data on file. Image on right: Copyright Steve Gschmeissner/Science Photo Library.

Kerecis is pioneering the use of fish skin and fatty acids in the globally expanding field of cellular therapy.
Kerecis is part of Coloplast, the leading global supplier of intimate healthcare products.
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