Wound Therapeutic Area Approximator
This calculator is for informational purposes only and provides estimates based on user inputs. It does not constitute medical advice or guidance on product selection. Healthcare professionals must use their independent clinical judgment and consider individual patient needs. Kerecis makes no warranties regarding the accuracy or reliability of the results. Use of this tool does not guarantee clinical outcomes, reimbursement, or payment, and all reliance is at the user's own risk.
This calculator is intended for use in relation to the MariGen product.
Clinical Narrative Example
References
“Skin substitutes should also be flexible and easily adjustable to the wound bed in order to provide “intimate contact” (without “dead spaces”)”
Przekora, A. A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro? Cells 2020, 9, 1622. https://doi.org/10.3390/cells9071622 https://www.mdpi.com/2073-4409/9/7/1622?utm_
Importance of Overlap in Wound Coverage
When selecting a wound dressing, it is important to consider an overlap margin around the wound edges to ensure complete coverage and protection. An overlap of at least 0.5 cm is often recommended to account for wound contraction and movement, which can help prevent dressing displacement and reduce the risk of infection.
Skin substitute should conform to the entire wound surface
Kallis PJ, Friedman AJ, Lev-Tov H. A Guide to Tissue-Engineered Skin Substitutes. J Drugs Dermatol. 2018 Jan 1;17(1):57-64. PMID: 29320588.
When skin product is applied, coverage of the entire wound surface is expected
Wounds International. When skin product is applied, coverage of the entire wound surface is expected. https://woundsinternational.com/wp-content/uploads/2024/12/MULTI24_CD_Skin-substitues_WINT_WEB.pdf?…
Skin substitute products should cover the entire wound bed
Snyder D, Sullivan N, Margolis D, et al. Skin Substitutes for Treating Chronic Wounds. Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Feb 2. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554222/?utm
Fixation is required to resist shear forces and allow integration into the wound bed
Vecin NM, Kirsner RS. Skin substitutes as treatment for chronic wounds: current and future directions. Front Med (Lausanne). 2023 Aug 29;10:1154567. doi:10.3389/fmed.2023.1154567. PMID: 37711741; PMCID: PMC10498286.
Fixation improves “graft take”
Patel BJ, Asher CM, Bystrzonowski N, Healy C. Safeguarding Skin Grafts: An Evidence-Based Summary of Fixation Techniques. Ann Plast Surg. 2021 Dec 1;87(6):e180-e188. doi:10.1097/SAP.0000000000002937. PMID: 34117134.