MariSurgi - Kerecis

MariSurgi is intact fish skin intended for the management of trauma wounds and surgical wounds in the operating room.[3,5] Because there is no known risk of viral transfer from North Atlantic cod to humans, the fish skin only needs mild processing with our proprietary method.[1,2]

This process preserves the skin’s natural qualities,[3] including: its three-dimensional structure, mechanical properties, molecular organization, and composition.[1,2,3,5]

The product is homologous to human skin[5] and when applied to damaged tissue or wounds, it helps to support the body’s own cells to regenerate tissue.[1,3,5]

MariSurgi™ Benefits

Easy to Apply[6]

Homologous to Human Skin[5]

Improved Wound Closure Rates[1,7,8]

Better Functional Outcome[9]

No Chemical Cross-linking[5]

Dermal and Epidermal Layers Intact[5]

Natural Microbial Barrier and Wound Cover[2,3,5]

Strong, Robust and Conforms to the Wound Bed[5]

Three-dimensional Structure and Natural Porosity Preserved[5]

3-year shelf life with easy storage at or below room temperature

MariSurgi Product Variations

MariSurgi

Standard

MariSurgi Standard is an intact fish-skin graft used for supporting tissue regeneration on surgical, traumatic and acute wounds.

Description & Sizing

SKU

Coverage

1,75x1,75cm Solid

50205S00D0B

3,1 cm²

3x3,5 cm, Solid

50205S01D0B

10,5 cm²

3x7 cm, Solid

50205S02D0B

21 cm²

5x7 cm, Solid

50205S05D0B

35 cm²

7x7 cm, Solid

50205S04D0B

49 cm²

7x10 cm, Solid

50205S03D0B

70 cm²

7x20 cm, Solid

50205S21D0B

140 cm²

16 mm, circular

50205S16D0B

2 cm²

Developed for acute, trauma and surgical wounds

MariSurgi can be used on patients, 18 years or older for a variety of wound types, including:

Partial and full-thickness wounds
Diabetic foot ulcers
Venous ulcers
Arterial ulcers
Partial-thickness burns
Trauma wounds (including abrasions, lacerations, skin tears)
Acute and chronic surgical wounds (including post amputation, dehiscence, and auto-graft donor sites)

Instructions for Use (MDR)

Need more information?

From the town of Ísafjörður in northwest Iceland, Kerecis develops, manufactures, and distributes patented fish-skin medical devices that support soft tissue regeneration in the body, with regulatory clearance in the United States, Europe, and beyond.

Important Information

This website and its content is not intended to provide diagnosis, treatment, or medical advice. Products, services, information, and other content provided on this website, including information provided directly or through links to third-party websites, are for informational purposes only. Information on this website should not be considered a substitute for professional advice from a healthcare provider. Always consult with a physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options.

Products and their variations may not be available in all countries and could be known under different trade names. Products, product names, indications, and claims vary by jurisdiction. Always verify with your local healthcare professional and consult the printed package information before use. Information on this website may not be current and might not reflect the latest product labeling – please refer to latest IFU’s on the website. For questions about product availability, please contact your Kerecis representative or use the contact form on our website.

Products are derived from fish sources and should not be used in patients with a known allergy to fish or sensitivity to fish products. Note that fish allergy is distinct from shellfish allergy. Do not apply fish skin products over infected or deteriorating wounds until the underlying cause has been resolved.

SurgiClose Silicone and Shield products contain silicone and are not suitable for patients with silicone sensitivity.
SurgiBind is not indicated for procedures requiring load-bearing support, such as hernia repair, for intraperitoneal organ contact, or where a bridging effect is needed.
SurgiBind Tendon Protect is not indicated to replace or repair the damaged tendon or to reinforce the strength of any tendon repair.
Always follow the product’s labeling for indications and contraindications.

A surgeon must always rely on their professional clinical judgment when deciding whether to use a specific product for a patient. Kerecis does not dispense medical advice and strongly recommends that surgeons be adequately trained in the use of its products before employing them in surgical procedures. The information provided on this website is intended to demonstrate the product offerings and should not replace the package insert, product label, or instructions for use. For regulatory and medical practice reasons, product availability may vary by market. Contact your Kerecis representative for further clarification.

For single patient use only; do not reuse, reprocess, or re-sterilize.
Discard any unused portions of the product.
Sterile only if the package is unopened and undamaged.
Do not use the product if the package seal has been broken, unintentionally opened, or if handling has caused damage or contamination.
Do not use after the expiration date printed on the product label or packaging.
Remove all non-viable and necrotic tissue prior to application of the product.
Remove exudate and control bleeding prior to product application.
Do not use in patients with known fish allergies.
The product is not designed, sold, or intended for use except as indicated.
No clinical trials have been conducted in pediatric, pregnant, or breastfeeding populations.

Baldursson, B. T. et al. Healing rate and autoimmune safety of fullthickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: a non-inferiority study. Int. J. Low. Extrem. Wounds 14, (2015).

Rakers, S. et al. ‘Fish matters’: the relevance of fish skin biology to investigative dermatology. Exp. Dermatol. 19, 313–324 (2010).

Magnusson, S. et al. Decellularized fish skin: characteristics that support tissue repair. Laeknabladid 101, 567–573 (2015).

⁴

Wang, Y., et al. Burn injury: challenges and advances in burn wound healing, infection, pain and scarring. Adv Drug Deliv Rev. 123, 3-17 (2018).

⁵

Magnusson, S., Baldursson, B. T., Kjartansson, H., Rolfsson, O. & Sigurjonsson, G. F. Regenerative and Antibacterial Properties of Acellular Fish Skin Grafts and Human Amnion/ Chorion Membrane: Implications for Tissue Preservation in Combat Casualty Care. Mil. Med. 182, 383–388 (2017).

⁶

Pujji O, Jeffery SLA, Safe burn excision prior to military repatriation: an achievable goal? BMJ Military Health 2018;164:358-359.

⁷

Kirsner, R. S. et al. Double-Blind, Prospective, Randomized Clinical Trial on 170 Acute Wounds Shows Significantly Faster Healing Rate with Intact Fish Skin Compared to Human Amniotic Membrane. Natl. Am. Podiatr. Med. Assoc. Annu. Sci. Meet. (2018).

⁸

Lullove E. J. et al. A multicenter, blinded, randomized controlled clinical trial evaluating the effect of Omega-3– rich fish skin in the treatment of chronic, nonresponsive diabetic foot ulcers. Wounds. Published online April 15, 2021.

⁹

Wallner C. et al. A Comparison of Intact Piscine Skin, Split-thickness Skin Graft, and Lactic Acid Membrane in Treating Superficial and Deep Burn Wounds Following Enzymatic Debridement. J Burn Care Res. 2021; 42 (Suppl 1): 125-126.

¹⁰

Patel, M. & Lantis II, J. C. Fish skin acellular dermal matrix: potential in the treatment of chronic wounds. Chronic Wound Care Manag. Res. 6, 59–70 (2019).

¹¹

Dardari et al. Intact Fish Skin Graft to Treat Deep Diabetic Foot Ulcers: The Odinn Trial. NEJM Evidence. 2024: 5. DOI: 10.1056/EVIDoa2400171

¹²

Stone R 2nd, Saathoff EC, Larson DA, et al. Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft. Int J Mol Sci. 2021;22(4):1590.

MariSurgi™